JH-XVII-10 [CAS 3034312-17-6]

JH-XVII-10 is a potent, selective and orally active DYRK1A and DYRK1B inhibitor with IC50s of 3 nM and 5 nM for DYRK1A and DYRK1B, respectively. JH-XVII-10 shows antitumor efficacy in neck squamous cell carcinoma (HNSCC) cell lines[1].

[3034312-17-6]

C22H18F4N8O

486.42

FC(F)(F)C1=NN2C=C1C3=C(F)NC4=NC=C(C=C43)C5=C(C#N)N(C)N=C5CN(C)C(CCC2)=O

Apoptosis; DYRK

DYRK1

10 mM in DMSO

Room temperature