Jingzhaotoxin-IX

Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3[1].

C171H251N49O48S6

3953.51

O=C([C@@H](N)CCC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CSSC[C@H](NC2=O)C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N)=O)CC3=CC=CC=C3)=O)[C@@H](C)O)=O)=O)CC(O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)CCC(O)=O)=O)CO)=O)CC(O)=O)=O)CCCCN)=O)[C@@H](C)O)=O)CSSC[C@H](N6)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N7[C@H](C(N[C@H](C(N[C@H]2CC8=CNC=N8)=O)CC9=CC=C(O)C=C9)=O)CCC7)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CCCCN)=O)[C@@H](C)O)=O)CSSC[C@H](NC1=O)C(N%12C(C(NC(C(NC(C(NCC6=O)=O)CC(C)C)=O)CC%13=CNC=N%13)=O)CCC%12)=O

Sodium Channel

10 mM in DMSO

Room temperature