JJC8-089 [CAS 1627576-64-0]

JJC8-089 is a dopamine transporter (DAT) inhibitor that may improve motivational dysfunction and increase effortful behavior in goal-directed activities. JJC8-089 significantly reversed the low-effort effects induced by the VMAT-2 inhibitor Tetrabenazine in rats and increased the choice of high-effort fixed-ratio 5-bar presses versus food intake.[2].

[1627576-64-0]

C22H28F2N2OS

406.53

CC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)O

Dopamine Transporter

10 mM in DMSO

Room temperature