JK-P3 is a potent and pan VEGFR2 inhibitor, with IC50s of 7.83 μM, 27 μM and 5.18 μM for VEGFR2, FGFR1 and FGFR3, respectively. JK-P3 can inhibit VEGF-A-stimulated VEGFR2 activation and intracellular signalling, also inhibits endothelial monolayer wound closure and angiogenesis, as well as fibroblast growth factor receptor kinase activity in vitro. JK-P3 has anti-angiogenic activity[1].
CAS Number
[942655-44-9]
Molecular Formula
C18H17N3O3
Molecular Weight
323.35
Smiles
O=C(NC1=NNC(C2=CC=CC=C2)=C1)C3=CC=C(OC)C(OC)=C3
Target
FGFR; VEGFR
Isoform
VEGFR2/KDR/Flk-1
Purity
99.75
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)