JKC 301 [CAS 136553-96-3]

JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking[1][2].

[136553-96-3]

C32H44N6O7

624.73

O=C(N[C@@H](C(N(CCC1)[C@]1([H])C2=O)=O)CC(O)=O)[C@H](NC([C@@H](NC([C@@](N2)([H])[C@H](C)CC)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C34

Vasopressin Receptor

10 mM in DMSO

Room temperature