JKE-1674 [CAS 2421119-60-8]

JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors[1][2][3].

[2421119-60-8]

C20H20Cl2N4O4

451.3

O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)/C(C[N+]([O-])=O)=N/O

Ferroptosis; Glutathione Peroxidase

GPX4

10mM

99.54

DMSO : 100 mg/mL (ultrasonic) |Ethanol : ≥ 50 mg/mL

4°C (Powder, protect from light)

Room Temperature