JMV 390-1 [CAS 148473-36-3]

JMV 390-1 (Compound 6a) is a potent multipeptidase inhibitor. JMV 390-1 behaves as a full inhibitor of the major neurotensin (NT) /neuromedin N (NN) degrading enzymes in vitro with IC50 values from 30 to 60 nM. JMV 390-1 increases endogenous recovery of NT and NN from slices of mice hypothalamus depolarized with potassium[1].

[148473-36-3]

C23H35N3O6

449.54

O=C(N[C@H](C(O)=O)CC(C)C)[C@H]([C@@H](C)CC)NC([C@@H](CC(NO)=O)CC1=CC=CC=C1)=O

Neurotensin Receptor

10 mM in DMSO

Room temperature