JNJ-10198409 [CAS 627518-40-5]

JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor (IC50=2 nM) . It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM) [1][2].

[627518-40-5]

C18H16FN3O2

325.34

COC1=CC2=C(C=C1OC)CC3=C2NN=C3NC4=CC=CC(F)=C4

PDGFR

PDGFRα; PDGFRβ

99.58

DMSO : 83.33 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice

H302, H315, H319, H335

H302, H315, H319, H335