JNJ-42259152 [CAS 1301167-87-2]

JNJ-42259152 is a phosphodiesterase 10A (PDE10A) positron emission tomography (PET) tracer that is specific for PDE10A activity. JNJ-42259152 can be dynamically scanned in healthy volunteers to assess its kinetic properties in the brain. The half-life of JNJ-42259152 in the blood is an average of 90 minutes. JNJ-42259152 has demonstrated reliable binding potential (BPND) in different target areas (such as the lentiform nucleus, caudate nucleus, ventral striatum, etc.), providing an important tool for studying neuropsychiatric diseases[1].

[1301167-87-2]

C24H23FN4O

402.46

CC1=CN=C(C(C)=C1)COC2=CC=C(C=C2)C3=NN(C=C3C4=CC=NC=C4)CCF

Phosphodiesterase (PDE)

Room temperature