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JNK-IN-12
JNK-IN-12
SKU:QM-0071539
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Product Details
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Description
JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor (IC50=66.3 nM), consisting of a mitochondrial-specific cell-penetrating peptide and a specific inhibitor of JNK, SP600125. JNK-IN-12 doesn't inhibit nuclear JNK signaling, but does inhibit mitochondrial JNK phosphorylation. JNK-IN-12 helps to improve the Parkinson's disease (PD) both in vitro and in vivo[1].
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Molecular Formula
C56H82N16O7
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Molecular Weight
1091.35
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Smiles
O=C1C2=C(NCCNC(CCCC3=CN(CCCC(N[C@H](C(N[C@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CC4CCCCC4)=O)=O)CC5CCCCC5)=O)N=N3)=O)C=CC=C2C6=NNC7=C6C1=CC=C7
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Target
JNK
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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JNK-IN-12
JNK-IN-12 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.