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JP-163-16

JP-163-16

Size

QM-0012453-01

£482.54 GBP
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Product Details

  • Description

    JP-163-16 is a RelA/p65 PROTAC degrader. JP-163-16 selectively reduces the expression of RelA/p65 in a proteasome-dependent manner in cells. JP-163-16 can induce cell apoptosis by inhibiting the NF-κB signaling pathway. JP-163-16 can be used for research on RelA/p65-dependent tumours, such as chronic lymphocytic leukaemia (CLL). (Pink: RelA/p65 Ligand ; Blue: CRBN Ligand (HY-A0003) ; Black: Linker; CRBN Ligand+Linker (HY-160241) ).

  • Molecular Formula

    C42H47N7O8

  • Molecular Weight

    777.86

  • Smiles

    O=C(NC1=CC=C(NC(CCCOC2=C(OC)C=C3C(N=C[C@@](CCC4)([H])N4C3=O)=C2)=O)C=C1)CCCCCNC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O

  • Target

    Apoptosis; NF-κB; PROTACs

  • Isoform

    Cereblon; RelA/p65

  • Shipping Conditions

    Room temperature
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Variant Variant total Quantity Price Variant total
1 mgQM-0012453-01
1 mgQM-0012453-01
£320.40
£482.54/ea
 £0.00
£320.40
£482.54/ea
 £0.00
5 mgQM-0012453-02
5 mgQM-0012453-02
£804.60
£1,136.21/ea
 £0.00
£804.60
£1,136.21/ea
 £0.00
10 mgQM-0012453-03
10 mgQM-0012453-03
£1,287.90
£1,788.66/ea
 £0.00
£1,287.90
£1,788.66/ea
 £0.00
25 mgQM-0012453-04
25 mgQM-0012453-04
£2,570.40
£3,520.04/ea
 £0.00
£2,570.40
£3,520.04/ea
 £0.00
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JP-163-16

JP-163-16 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.