JPS004 [CAS 2559747-12-3]

JPS004 is a HDAC1-3 PROTAC degrader. JPS004 can induce degradation of HDAC1-3 and induce histone acetylation. JPS004 can induce cancer cells apoptosis. JPS004 can be used for the research of cancer[1]. (Structure Note: Pink: HDAC1-3 ligand ; Blue: VHL ligand (HY-125845) ; HDAC1-3 ligand-Linker: (HY-176905) )

[2559747-12-3]

C47H61N7O6S

852.1

NC(C=CC=C1)=C1NC(C(C=C2)=CC=C2NC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(NCC4=CC=C(C5=C(N=CS5)C)C=C4)=O)=O)=O)=O)=O

Apoptosis; HDAC; PROTACs

HDAC1; HDAC2; HDAC3; von Hippel-Lindau (VHL)

Room temperature