JPS016 (TFA)

JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC) . JPS016 degrades class I histone deacetylase (HDAC) . JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

C50H64F3N7O10S

1012.14

O=C(N(C[C@@H]1O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCCCCCCCCOCC(NC(C=C4)=CC=C4C(NC(C=CC=C5)=C5N)=O)=O)=O.OC(C(F)(F)F)=O

HDAC; PROTACs

99.47

DMSO : 100 mg/mL (ultrasonic)

-20°C (Powder, protect from light, stored under nitrogen)

Blue Ice