(+) -JQ1-OH

(+) -JQ1-OH is the major metabolite of (+) -JQ1. (+) -JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4 (1/2) ). (+) -JQ-1 also activates autophagy[1].

C23H25ClN4O3S

472.99

OCC(S1)=C(C)C2=C1N3C([C@H](CC(OC(C)(C)C)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C

Drug Metabolite

10 mM in DMSO

Room temperature