JTE-607 (free base) [CAS 188791-71-1]

JTE-607 free base, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 free base inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively[1]. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 free base[2].

[188791-71-1]

C25H31Cl2N3O5

524.44

O=C([C@@H](NC(C1=CC(Cl)=C(C(Cl)=C1O)OCCN2CCN(CC2)C)=O)CC3=CC=CC=C3)OCC

Interleukin Related

Room temperature