JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC50 of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity[1].
CAS Number
[339103-05-8]
Molecular Formula
C13H7Cl2N3O
Molecular Weight
292.12
Smiles
ClC1=CC(Cl)=C(C2=NC(C3=CC=CC=N3)=NO2)C=C1
Target
FOXO
Concentration
10mM
Purity
99.75
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)