JY-21

JY-21 is a BRD4 PROTAC degrader with a DC50 of 3.797 μM. JY-21 has a potent anticancer activity against MDA-MB-231 cells[1]. Pink: BRD4 ligand ; Blue: E3 ligase ligand (HY-174994) ; Black: linker (HY-151862)

C42H50ClN11O4SSi

868.52

CC1=C(C(C(C2=CC=C(C=C2)Cl)=N[C@H]3CC(NCCCN4C=C(N=N4)COC5=CC=C(C([N+]([O-])=O)=C5)/N=N/C#C[Si](C(C)C)(C(C)C)C(C)C)=O)=C(N6C3=NN=C6C)S1)C

Epigenetic Reader Domain; PROTACs

BRD4

Room temperature