JYQ-173

JYQ-173, a chemical probe, is a selective inhibitor for human Parkinson disease protein 7 (PARK7), with an IC50 of 19 nM. JYQ-173 exhibits good cell permeability. JYQ-173 is the ligand for target protein PARK7, which can be utilized for synthesis of PROTAC Degrader JYQ-194.

C21H19FN8O2S

466.49

O=C([C@H]1CN(C#N)CC1)NC(S2)=NC3=C2CN(C(C4=C(F)C=CC(N5C=CN=N5)=C4)=O)CC3

Ligands for Target Protein for PROTAC

99.78

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice