K20

K20 is a potent and selective KRas G12C inhibitor with an IC50 of 1.16 μM. K20 shows anticancer activity in H358 cells (IC50= 0.78 μM) . K20 decreases the levels of phosphorylated Erk and leads to cancer cell apoptosis. K20 suppresses NCI-H358 tumor growth with a TGI of 41% without causing obvious toxicity[1].

C24H20Cl2F4N4O2

543.34

C=C(C(N1CCN([C@@H](C1)C)C2=NC=NC3=C(C(C4=CC(Cl)=CC=C4OC)=C(C=C23)Cl)F)=O)C(F)(F)F

Apoptosis; ERK; Ras

K-Ras

10 mM in DMSO

Room temperature