KB-15

KB-15 is a STAT3 inhibitor. KB-15 exhibits potent anti-proliferative activity against AGS gastric cancer cells (IC50 = 0.29 μM) and BGC-823 gastric cancer cells (IC50 = 0.65 μM) . KB-15 exerts anti-tumor effects by inhibiting STAT3 phosphorylation, downregulating HO-1 expression, and promoting intracellular ROS accumulation. KB-15 induces G0/G1 phase cell cycle arrest and apoptosis, as well as suppresses colony formation and migration of gastric cancer cells. KB-15 demonstrates excellent anti-tumor efficacy in BGC-823 subcutaneous xenograft model. KB-15 can be used for the study of gastric cancer[1].

C18H12Cl4N2O2

430.11

ClC1=C(Cl)C=CC(/C=C/C(NNC(/C=C/C2=CC(Cl)=C(Cl)C=C2)=O)=O)=C1

Apoptosis; PARP; Reactive Oxygen Species (ROS) ; STAT

Room temperature