KBD4466 [CAS 3023713-87-0]

KBD4466 is an orally active potent TLR7 and TLR8 inhibitor with IC50s of 0.9 nM and 2.8 nM, respectively. KBD4466 inhibits the expression of inflammatory cytokines IL-6 and IFN-α. KBD4466 improves disease progression and survival in the BXSB/MpJ mouse model of Systemic Lupus Erythematosus (SLE) . KBD4466 can be used in the study of autoimmune diseases[1].

[3023713-87-0]

C24H23F3N6O

468.47

CN1CCC(C2=NN=C([C@]34CN(C[C@]3(C4)C(F)(F)F)C5=C6C=CC=NC6=C(C=C5)C#N)O2)CC1

IFNAR; Interleukin Related; Toll-like Receptor (TLR)

IL-6; TLR7; TLR8

Room temperature