Keap1-IN-2 [CAS 3066895-41-5]

Keap1-IN-2 (Compound 164) is a KEAP1 inhibitor (IC50: 2 nM) . Keap1-IN-2 indirectly activates Nrf2 by inhibiting KEAP1, thereby enhancing the antioxidant capacity of cells. Keap1-IN-2 promotes the accumulation and nuclear translocation of Nrf2 by blocking KEAP1-mediated Nrf2 degradation. Keap1-IN-2 can be used to study diseases associated with oxidative stress, such as inflammatory bowel disease, Crohn's disease, and immune diseases such as ulcerative colitis[1].

[3066895-41-5]

C21H23ClN6O3

442.9

CC(N1[C@H](C2=CC(Cl)=NC(C3=NC=NC(C(NC)=O)=C3)=C2)CN(C[C@H]1C)C(C=C)=O)=O

Keap1-Nrf2

Room temperature