Keap1-Nrf2-IN-18

Keap1-Nrf2-IN-18 (Compound 22) is an orally active Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with good pharmacokinetics (PK) profiles and more potent in vivo activities in rats. Keap1-Nrf2-IN-18 has the strongest inhibitory activity in structure−activity relationship (SAR) study (KD = 0.0029 μM) [1].

C27H29FN2O4

464.53

CC1=CC=C([C@@H](NC([C@H](C2=CC=C(CC3=NC=CC=C3OCC)C=C2)F)=O)[C@@H](C)C(O)=O)C=C1

Keap1-Nrf2

10 mM in DMSO

Room temperature