Keap1-Nrf2-IN-27

Keap1-Nrf2-IN-27 (compound 1C) is a inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) with KD2 value of 0.119 μM. Keap1-Nrf2-IN-27 suppresses the expression of pro-inflammatory cytokine TNF-α and IL-6 in the LPS-induced RAW264.7 cell model[1].

C31H29N5O10S2

695.72

O=C(O)/C=C\C(NC1=CC=C(S(=O)(N(CC(N)=O)C2=C3C=CC=CC3=C(N(CC(N)=O)S(=O)(C4=CC=C(OC)C=C4)=O)C=C2)=O)C=C1)=O

Keap1-Nrf2

Room temperature