Keap1-Nrf2-IN-9 [CAS 2769963-24-6]

Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC50 of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells[1].

[2769963-24-6]

C31H30N2O11S2

670.71

O=S(N(CC(O)=O)C1=CC=C(N(CC(O)=O)S(=O)(C2=CC=C(OC)C=C2)=O)C=C1OCC3=CC=CC=C3)(C4=CC=C(OC)C=C4)=O

Keap1-Nrf2

98.52

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature