KF-17625 [CAS 139339-02-9]

KF-17625 is an orally active bronchodilator. KF-17625 can inhibit bronchoconstriction induced by Carbachol , Histamine (HY-B1204), or Leukotriene D4 (HY-113456). KF-17625 can inhibit canine tracheal phosphodiesterase (PDE) IV (IC50 = 12 μM) and Concanavalin-A (HY-P2149) -induced histamine release from rat mast cells (44% inhibition at 10 mM). KF-17625 can be used for the researches of immunology and inflammation[1].

[139339-02-9]

C15H10N4O

262.27

O=C1C2=C(C3=C(N1C4=CC=CC=C4)N=CC=C3)NC=N2

Histamine Receptor; Phosphodiesterase (PDE)

PDE4

Room temperature