KI-TOX-A3 [CAS 1351116-34-1]

KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor targeting TOX protein (with an IC50 value of 0.51 μM for TOX-KAT7 interaction) . KI-TOX-A3 induces proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reversing CD8+ T cell exhaustion and inhibiting T-cell acute lymphoblastic leukemia (T-ALL) cell proliferation. KI-TOX-A3 is promising for research of hematological tumors (e.g., T-ALL) [1].

[1351116-34-1]

C18H13N3O3

319.31

OCC1=CC=C(C2=C(CC3=C4C=CC(O)=C3)C4=NC(N)=C2C#N)O1

Histone Acetyltransferase

99.15

DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years (Powder)

Blue Ice