KIRA9 [CAS 2922507-65-9]

KIRA9 is a potent IRE1 inhibitor (IC50=4.8 μM in INS-1 cells) . KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis[1].

[2922507-65-9]

C27H27F3N6O3S

572.6

O=S(NC1=CC=C(OC2=NC=CC=C2C3=CC=NC(N[C@@H]4CNCCC4)=N3)C5=C1C=CC=C5)(CCC(F)(F)F)=O

Apoptosis; IRE1

10 mM in DMSO

Room temperature