KLHL3 serves as a substrate-specific linker in the BCR E3 ubiquitin ligase complex and is critical for ion transport in the distal nephron. The BCR (KLHL3) complex coordinates the degradation of WNK1, WNK4, WNK3, and CLDN8, fine-tunes NaCl reabsorption, and maintains electrolyte balance. KLHL3 Protein, Human (sf9) is the recombinant human-derived KLHL3 protein, expressed by sf9 insect cells , with tag free.
