KPC-2-IN-1 [CAS 2232877-85-7]

KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with Ki of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics[1][2].

[2232877-85-7]

C13H12BN3O2S

285.13

OB(C1=CC=CC(CN2N=NC(C3=CSC=C3)=C2)=C1)O

Bacterial

10 mM in DMSO

Room temperature