KPC-2-IN-3

KPC-2-IN-3 (Compound 3b) is a KPC-2 inhibitor with IC50 of 0.533 μM and Kiof 0.194 μM. KPC-2-IN-3 has an antimicrobial activity against carbapenem-resistant K. pneumonia K47-25 and reduces bacterial count with a postantibiotic effect in synergy with Meropenem. KPC-2-IN-3 significantly reduces lung bacterial load in a murine pneumonia model[1].

C8H9BFO5P

245.94

FC1=CC=C(C(B(O)O)=C1)/C=C/P(O)(O)=O

Bacterial

Room temperature