KPC-IN-1

KPC-IN-1 (compound 1e) is an inhibitor of Klebsiella pneumoniae carbapenemase KPC-2 (IC50=8.3 nM) . KPC is a β-lactamase expressed in Gram-negative bacteria that hydrolyzes carbapenems. KPC causes significant bacterial resistance to carbapenem antibiotics[1].

C10H7BFNO4

234.98

FC1=CC2=CC=CC(B(O)O)=C2N=C1C(O)=O

Bacterial

Room temperature