Kurtoxin

Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca2+ channel gating inhibitor with a Kd of 15 nM for Cav3.1 (α1G T-type) Ca2+ channel. Kurtoxin can interact with high affinity with native neuronal high-threshold L-type, N-type, and P-type Ca2+ channels in central and peripheral neurons. Kurtoxin also shows cross-reactivity with voltage-gated Na+ channel[1].

C324H478N94O90S8

7386.36

O=C(NC([C@H](C)CC)C(N[C@@H](CC(O)=O)C(NCC(N[C@H](CC1=CC=C(C=C1)O)C(N2[C@H](CCC2)C(NC(C(C)C)C(NC(CC(O)=O)C(NC(CC3=CC=C(C=C3)O)C(NC(CC4=CNC5=CC=CC=C45)C(NC(CC(N)=O)C(NC(CSSC[C@H](C(NC(CCCNC(N)=N)C(NC(C)C(O)=O)=O)=O)NC6=O)C(NC(CCCCN)C(NC(CCCNC(N)=N)C(NC(C(C)CC)C(NC(CSSCC(C(NC(CC7=CNC8=CC=CC=C78)C(NCC(NC(CC9=CNC%10=CC=CC=C9%10)C(NC(C(O)C)C(NC(CC(C)C)C(NC%11CO)=O)=O)=O)=O)=O)=O)NC%12=O)C(NC(CC%13=CNC%14=CC=CC=C%13%14)C(NC(CC%15=CC=C(C=C%15)O)C(NC(CC(N)=O)C(NC(CC(N)=O)C(NC(CCCCN)C(NC(CC%16=CC=C(C=C%16)O)C(NC(CSSCC(C(NC%17CC%18=CC=C(C=C%18)O)=O)NC%11=O)C(NC(CC(N)=O)C(NC(CC(O)=O)C(NC(CC(C)C)C(NC(CSSCC(C(NC(CCC(N)=O)C(NCC(NC(CC(C)C)C(N%19[C@@H](CCC%19)C(N[C@@H](CC(O)=O)C(N[C@H](CC(N)=O)C(NC(C)C(N[C@H](CCCNC(N)=N)C(N[C@H]([C@@H](C)CC)C(N[C@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(N[C@H](CO)C(NCC(N[C@@H]6CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%17=O)C(NC(CCCCN)C(NCC(NC(CC(C)C)C(NC(CCCCN)C(NC(C)C(NC(CC(O)=O)C(NC(CO)C(NCC(NC%12CC%20=CC=C(C=C%20)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(CCCCN)N

Calcium Channel; Sodium Channel

10 mM in DMSO

Room temperature