Kv2.1-IN-1 [CAS 2252448-93-2]

Kv2.1-IN-1 is an orally active and blood-brain barrier penetrant Kv2.1 inhibitor with an IC50 of 0.07 μM. Kv2.1-IN-1 exhibits a selectivity >130 fold over other K+, Na+, and Ca2+ ion channels. Kv2.1-IN-1 decreases the apoptosis of HEK293 cells induced by H2O2. Kv2.1-IN-1 produces significant neuroprotection efficacy in middle cerebral artery occlusion (MCAO) rat. Kv2.1-IN-1 can be used for the study of ischemic stroke[1].

[2252448-93-2]

C22H29N3O3

383.48

O=C(C1=CC(NC(C(C)C)=O)=CC=C1OCC)NC(C2=CC=CC(NC)=C2)C

Apoptosis; Potassium Channel

98.64

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature