KW-2478 [CAS 819812-04-9]

Name: KW-2478 [CAS 819812-04-9]
Brand: QuantiMol
SKU: QM-0144816-01
Price: 238.32 GBP
Availability: InStock

Size 5 mg 10 mg 10 mM - 1 mL 50 mg 100 mg

SKU:QM-0144816-01

£238.32 GBP

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Product Details

Description
KW-2478 is an HSP90 inhibitor (IC50 = 3.8 nM) . KW-2478 inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 downregulates STAT3 expression. KW-2478 may be used in research on cancers such as CML and liver cancer[1][2].
CAS Number
[819812-04-9]
Molecular Formula
C30H42N2O9
Molecular Weight
574.66
Smiles
O=C(N(CCOC)CCOC)CC1=C(C(C2=CC=C(OCCN3CCOCC3)C(OC)=C2)=O)C(O)=CC(O)=C1CC
Target
Apoptosis; Bcr-Abl; CDK; HSP; p38 MAPK; STAT
Isoform
HSP90
Purity
99.53
Solubility
DMSO : 200 mg/mL (ultrasonic)
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping Conditions
Room Temperature
Hazard Statement
H302, H315, H319, H335
Precautions
H302, H315, H319, H335

Your cart
Variant	Variant total	Quantity	Price	Variant total
5 mgQM-0144816-01	5 mgQM-0144816-01 £238.32/ea	£0.00	Quantity	£238.32/ea	£0.00

10 mgQM-0144816-02	10 mgQM-0144816-02 £351.32/ea	£0.00	Quantity	£351.32/ea	£0.00

10 mM - 1 mLQM-0144816-03	10 mM - 1 mLQM-0144816-03 £381.69/ea	£0.00	Quantity	£381.69/ea	£0.00

50 mgQM-0144816-04	50 mgQM-0144816-04 £803.30/ea	£0.00	Quantity	£803.30/ea	£0.00

100 mgQM-0144816-05	100 mgQM-0144816-05 £1,104.62/ea	£0.00	Quantity	£1,104.62/ea	£0.00

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KW-2478 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.