KWZY-11

KWZY-11 (Compound 11) is a potent PARP/CDK6 dual inhibitor with IC50 values of 156.8, 197.3, and 13.3 nM for PARP1, PARP2, and CDK6, respectively. KWZY-11 inhibits tumor cell proliferation by regulating the Wnt/β-catenin signaling pathway. KWZY-11 induces excessive DNA damage and apoptosis in MDA-MB-231 breast cancer cells[1].

C28H27ClN8O2

543.02

O=C(C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C5=NC6=C(N5)C=CC=C6C(N)=O)Cl)N(C)C

Apoptosis; CDK; PARP; Wnt; β-catenin

CDK6; PARP1; PARP2

Room temperature