L-652343 [CAS 107008-29-7]

L-652343 is a dual cyclooxygenase/lipoxygenase inhibitor. L-652343 can inhibit the production of LTB4 in isolated human polymorphonuclear leukocytes treated with Calcimycin (IC50: 1.4 μM), but it is inactive in whole blood. L-652343 can be used in the research of inflammatory and immune diseases[1].

[107008-29-7]

C22H14F3NO2S2

445.48

OC1=C(C(N/C=C(C2=CC=CC=C2)/C3=CC=CS3)=O)SC4=C1C=C(C(F)(F)F)C=C4

COX; Leukotriene Receptor; Lipoxygenase

LTB4

Room temperature