L-669083 [CAS 130007-52-2]

L-669083 is a leukotriene biosynthesis inhibitor whose structure is based on a mixture of indole and quinoline. In this study, a potent radioiodinated photoaffinity analog of L-689,037, [125I] L-691,678, was developed and characterized for immunoprecipitation studies showing that the quindole series of leukotriene biosynthesis inhibitors directly interact with FLAP. In addition, the results showed that MK-886, L-674,573, and L-689,037 competed with [125I] L-691,678 and [125I] L-669083 for binding to FLAP in a concentration-dependent manner, indicating that these three leukotriene biosynthesis inhibitors share a binding site on FLAP, further demonstrating that FLAP is a suitable target for structurally diverse leukotriene biosynthesis inhibitors.

[130007-52-2]

C29H29IN4O5S

672.53

[N-]=[N+]=NC1=CC=C(S(=O)(C2=C(CC(C)(C)C(O)=O)N(CC3=CC=C(C(I)=C3)O)C4=C2C=C(C(C)C)C=C4)=O)C=C1

FLAP

Room temperature