L 738372 [CAS 159565-60-3]

L-738372 is a non-competitive reversible inhibitor of HIV-1 reverse transcriptase (RT) with an inhibition constant (Ki) of 140 nM against dTTP. When combined with any nucleoside analogs (such as azidothymidine triphosphate, didexoyinosine triphosphate, or didexoycytidine triphosphate), L-738372 exhibits synergistic inhibition of RT activity. L-738372 has 2-3 times more inhibitory potency against the azidothymidine-resistant RT (D67N, K70R, T215Y, K219Q) compared to the wild-type RT. L-738372 holds promise for research in the field of HIV virus treatment[1].

[159565-60-3]

C18H15N3O

289.33

O=C1NC2=C([C@@](C#CC3=NC=CC=C3)(C4CC4)N1)C=CC=C2

HIV

HIV-1

Room temperature