L-873724 [CAS 603139-12-4]

L-873724 is a potent, orally bioavailable, selective and reversible[2] non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively[1]. L-873724 also exhibits an IC50 of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption[2].

[603139-12-4]

C23H26F3N3O3S

481.53

O=S(C1=CC=C(C2=CC=C([C@@H](C(F)(F)F)N[C@@H](CC(C)C)C(NCC#N)=O)C=C2)C=C1)(C)=O

Cathepsin

Cathepsin B; Cathepsin K

98.93

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature