L-Asparagine-13C4,15N2 [CAS 781596-75-6]
L-Asparagine-13C4,15N2 [CAS 781596-75-6]
SKU:QM-0098047
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Product Details
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Description
L-Asparagine-13C4,15N2 ((-) -Asparagine-13C4,15N2) is the 13C and 15N-labeled L-Asparagine. L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6].
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CAS Number
[781596-75-6]
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Molecular Formula
13C4H8 15N2O3
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Molecular Weight
138.08
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Smiles
[15NH2][13C]([13CH2][13C@H]([15NH2])[13C](O)=O)=O
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Target
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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L-Asparagine-13C4,15N2 [CAS 781596-75-6]
L-Asparagine-13C4,15N2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.