L-Asparagine-13C4,15N2, d3 (monohydrate) [CAS 2483829-30-5]
L-Asparagine-13C4,15N2, d3 (monohydrate) [CAS 2483829-30-5]
SKU:QM-0192813-01
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Product Details
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Description
L-Asparagine-13C4,15N2, d3 monohydrate is the deuterium, 13C-, and 15N-labeled L-Asparagine monohydrate. L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6].
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CAS Number
[2483829-30-5]
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Molecular Formula
13C4H7D3 15N2O4
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Molecular Weight
159.11
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Smiles
[15NH2][13C]([13C]([2H])([2H])[13C@@]([15NH2])([2H])[13C](O)=O)=O.O
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Target
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds
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Purity
99.9
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Solubility
H2O : 20 mg/mL (ultrasonic; warming)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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L-Asparagine-13C4,15N2, d3 (monohydrate) [CAS 2483829-30-5]
L-Asparagine-13C4,15N2, d3 (monohydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.