L-Asparagine-13C4,15N2, d8 [CAS 1217464-18-0]
L-Asparagine-13C4,15N2, d8 [CAS 1217464-18-0]
SKU:QM-0163055-01
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Product Details
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Description
L-Asparagine-13C4,15N2, d8 is the 13C-labeled and 15N-labeled L-Asparagine. L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6].
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CAS Number
[1217464-18-0]
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Molecular Formula
13C4D8 15N2O3
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Molecular Weight
146.12
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Smiles
[2H][15N]([2H])[13C]([13C]([2H])([2H])[13C@@]([15N]([2H])[2H])([2H])[13C](O[2H])=O)=O
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Target
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds
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Purity
99
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Solubility
10 mM in DMSO
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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L-Asparagine-13C4,15N2, d8 [CAS 1217464-18-0]
L-Asparagine-13C4,15N2, d8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.