L-Asparagine-13C4,15N2 (monohydrate) [CAS 202406-87-9]
L-Asparagine-13C4,15N2 (monohydrate) [CAS 202406-87-9]
SKU:QM-0199561-01
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Product Details
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Description
L-Asparagine-13C4,15N2 monohydrateis the 13C-labeled and 15N-labeled L-Asparagine monohydrate. L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6].
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CAS Number
[202406-87-9]
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Molecular Formula
13C4H7 15N2O4
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Molecular Weight
153.07
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Smiles
[15NH2][13C@]([13C](O)=O)[13C][13C]([15NH2])=O.O
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Target
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds
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Purity
98
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Solubility
10 mM in DMSO|DMSO : 1mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 20mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
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Shipping Conditions
Room Temperature
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L-Asparagine-13C4,15N2 (monohydrate) [CAS 202406-87-9]
L-Asparagine-13C4,15N2 (monohydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.