L-Asparagine-15N2, d3 (monohydrate)
L-Asparagine-15N2, d3 (monohydrate)
SKU:QM-0174063-01
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Product Details
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Description
L-Asparagine-15N2, d3 monohydrate is the deuterium and 15N-labeled L-Asparagine monohydrate. L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6].
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Molecular Formula
C4H7D3 15N2O4
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Molecular Weight
155.14
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Smiles
[15NH2][C@@](C(O)=O)([2H])C([2H])([2H])C([15NH2])=O.[H]O[H]
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Target
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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L-Asparagine-15N2, d3 (monohydrate)
L-Asparagine-15N2, d3 (monohydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.