L-Asparagine [CAS 70-47-3]
L-Asparagine [CAS 70-47-3]
SKU:QM-0163053-01
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Product Details
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Description
L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5].
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CAS Number
[70-47-3]
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Molecular Formula
C4H8N2O3
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Molecular Weight
132.12
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Smiles
N[C@H](C(O)=O)CC(N)=O
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Target
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite
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Isoform
Human Endogenous Metabolite; Microbial Metabolite
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Purity
98
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Solubility
H2O : 6.67 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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L-Asparagine [CAS 70-47-3]
L-Asparagine is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.