L-Asparagine-amide-15N (monohydrate) [CAS 204451-47-8]
L-Asparagine-amide-15N (monohydrate) [CAS 204451-47-8]
SKU:QM-0199086-01
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Product Details
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Description
L-Asparagine-amide-15N monohydrate is the 15N-labeled L-Asparagine monohydrate. L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6].
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CAS Number
[204451-47-8]
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Molecular Formula
C4H10N 15NO4
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Molecular Weight
151.13
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Smiles
[15NH2]C(C[C@H](N)C(O)=O)=O.[H]O[H]
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Target
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds
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Purity
99.8
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Solubility
DMSO : 1mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 20mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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L-Asparagine-amide-15N (monohydrate) [CAS 204451-47-8]
L-Asparagine-amide-15N (monohydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.