L-Asparagine (monohydrate) (Standard) [CAS 5794-13-8]
L-Asparagine (monohydrate) (Standard) [CAS 5794-13-8]
SKU:QM-0115791-01
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Product Details
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Description
L-Asparagine monohydrate (Standard) is the analytical standard of L-Asparagine monohydrate. This product is intended for research and analytical applications. L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5].
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CAS Number
[5794-13-8]
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Molecular Formula
C4H10N2O4
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Molecular Weight
150.13
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Smiles
N[C@H](C(O)=O)CC(N)=O.[H]O[H]
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Target
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite; Reference Standards
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Shipping Conditions
Room temperature
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L-Asparagine (monohydrate) (Standard) [CAS 5794-13-8]
L-Asparagine (monohydrate) (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.