L-Sepiapterin [CAS 17094-01-8]

L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4) . L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia[1][2].

[17094-01-8]

C9H11N5O3

237.22

O=C1NC(N)=NC2=C1N=C(C([C@@H](O)C)=O)CN2

Endogenous Metabolite

Human Endogenous Metabolite

99.5

DMSO : 10 mg/mL (ultrasonic;warming)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature