Larotrectinib sulfate [CAS 1223405-08-0]
Larotrectinib sulfate [CAS 1223405-08-0]
SKU:QM-0142480-01
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Product Details
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Description
Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C) .
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CAS Number
[1223405-08-0]
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Molecular Formula
C21H24F2N6O6S
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Molecular Weight
526.51
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Smiles
O=S(O)(O)=O.O=C(N1CC[C@H](O)C1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2
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Target
Apoptosis; Trk Receptor
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Isoform
TrkA; TrkB; TrkC
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Concentration
10mM
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Purity
99.21
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Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H319, H320
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Precautions
H315, H319, H320
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Larotrectinib sulfate [CAS 1223405-08-0]
Larotrectinib sulfate is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.